The fluorometric detection in lab-on-a-chip devices for life-sciences is one of the main detection methods. Well know from
"large-scale" analytical chemistry methodologies and instrumentation has been applied in lab-on-a-chip solutions. In most cases, optical
instrumentation for fluorescence induction and detection is based on configuration and components borrowed from large laboratory instruments.
As a result, optical instrumentation surrounding lab-on-a-chip is bulky, expensive and dedicated for operation only inside laboratory.
In this paper a discussion on fluorescence detection in lab-on-a-chip is carried out. A novel image sensor - based detection instrumentation
co-working with a "clever" software is described. Instrumentation is dedicated for operation in portable and low-cost devices for different
life-science applications. Examples of applications of the novel method and instrumentation co-working with various lab-on-a-chips are
presented on the base of author's works.
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