BULLETIN of the

POLISH ACADEMY of SCIENCES

TECHNICAL SCIENCES

BULLETIN of the POLISH ACADEMY of SCIENCES: TECHNICAL SCIENCES
Volume 53, Issue 4, December 2005

Micro and Nano -scale mechanics

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pp 325 - 334
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Numerical simulation of multiple species detection using hydrodynamic/electrokinetic focusing

J. Hahm, A. Beskok
In this paper we present the numerical simulation-based design of a new microfluidic device concept for electrophoretic mobility and (relative) concentration measurements of dilute mixtures. The device enables stationary focusing points for each species, where the locally applied pressure driven flow (PDF) counter balances the speciesí electrokinetic velocity. The axial location of the focusing point, along with the PDF flowrate and applied electric field reveals the electrokinetic mobility of each species. Simultaneous measurement of the electroosmotic mobility of an electrically neutral specie can be utilized to calculate the electrophoretic mobility of charged species. The proposed device utilizes constant sample feeding, and results in time-steady measurements. Hence, the results are independent of the initial sample distribution and flow dynamics. In addition, the results are insensitive to the species diffusion for large Peclet number flows (Pe > 400), enabling relative concentration measurement of each specie in the dilute mixture.
 
Keywords:

Species detection, electrophoresis, hydrodynamic/electrokinetic focusing, microfluidics

 
 
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12 January 2006, site prepared  by KZ